Saturday, September 8, 2012

Exacerbation Vs Corticosteroids

It was found that corticosteroids reduce the duration and severity of relapses and speed recovery, but not beyond a reasonable doubt that the increase of the overall rate of recovery, or that change the course of the disease in the long term.

ACTH (adrenocorticotropic hormone or ACTH) first drug to have proven effective in the recovery of acute exacerbations. Was administered intravenously methyl (IV) over short periods and at high doses (500 to 1000 mg MPIV / day for 3-5 days) ACTH largely because of its reliability, convenience suppress its image improve safety and perhaps put its consistent and faster. The extrapolation of the results of the study on the treatment of optic neuritis (inflammation of the optic nerve primary treatment) by neurologists many MS attacks in general.

In this study, 457 patients were randomly with optic neuritis to 1000 mg / day for 3 days on MPIV, then 1 mg / kg / day. Oral prednisone for 11 days, orally, 1 mg / kg / day of prednisone by mouth for 14 days or placebo feature study cases of inflammation of the optic nerve is the fact that also fits this requirement to assess the parameters sensitive (for example, the visual field, and contrast sensitivity, color vision and visual acuity).


At least 80 to 85 Percent of people with MS during periods of exacerbation of their symptoms go at one time or another. This is a large, and sometimes worsen, and attacks or crises that bear by the sudden onset of a neurological disorder known for at least 24 hours in the absence of fever or infection. Outbreak of symptoms varies greatly. Layouts magnetic resonance imaging (MRI) taken during deceleration often show new active lesions in the brain (it increases in the presence of gadolinium) or old pest activate or expanded. Although most episodes of spontaneous, most medical professionals agree on the necessity of the treatment if they have important functional implications are.

Corticosteroids are the cornerstone for many years for the treatment of acute exacerbations. Because immune and anti-inflammatory effects, to restore the integrity of the blood-brain barrier to facilitate the return of myelin edema and improve nerve impulses

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