Thursday, October 25, 2012
In a recently published the results of a multicenter European Phase II trial, which placebo-controlled, randomized, blind protocol.Found a significant positive impact on the frequency of relapses and the evolution of the deficit, and not accompanied by acute toxic effects. The information MRI beneficial effect on disease activity. Treatment was well tolerated. Although the results of this study led to the approval of mitoxantrone for the treatment of MS by the FDA in 2002, was not published the results in a scientific journal with peer review.
Home toxic effects of mitoxantrone is myelosuppression and cardiotoxicity dose.
Therefore, if the treatment with mitoxantrone, it is extremely important that patients who suffer from heart disease and an observer (depending on the treatment regimen used) ECG, blood and urine analysis to exclude the results on a monthly basis and an echocardiogram every six months.
Mitoxantrone is mediated antineoplastic agent with a strong immunological effects, including by inhibiting immune B cells and lymphocytes-T, is much less toxic anti-cancer drugs other, is the most common serious side effects cardiotoxicity. This compound is the subject of three trials for the treatment of MS in recent years.
Last placebo-controlled, randomized, conducted in Italy of 51 patients with RRMS. The treatment was to be in the 8 mg/m2 administered intravenously once a month for a year. A were measured downward trend in disease activity by evaluating clinical outcomes and magnetic resonance imaging (MRI) and shown in this study.
Conducted last placebo-controlled, randomized, with the expected duration of two years in Italy, from 51 patients with RRMS. The treatment was to be in the 8 mg/m2 administered intravenously once a month for a year. A were measured downward trend in disease activity by evaluating clinical outcomes and magnetic resonance imaging (MRI) and shown in this study.
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